A Universidade São Francisco irá promover no dia 27 de agosto, dás 19h as 21h, uma palestra Updates in Neuroscience com o tema “New Mechanism for Pain Control: Role of the Mitochondrial Aldehyde-Dehydrogenase-2” na Sala Web do Câmpus Bragança Paulista.
O evento trata-se de uma de quatro apresentações internacionais que serão realizadas no mês de agosto de 2019 referentes a atualizações em Neurociência promovido pelo Programa de Pós-Graduação Stricto Sensu em Ciências da Saúde.
O objetivo do evento é a discussão sobre dor neuropática.
O evento é gratuito e terá transmissão ao vivo. As inscrições podem ser realizadas pelo site.
Adequate control of neuropathic pain is still a challenge and an unmet clinical need. In addition, adverse effects and rapid development of tolerance have been associated to some of the drugs currently used for the treatment of pain, evidencing the need for new analgesic substances. Aldehyde-dehydrogenase 2 (ALDH-2) is a mitochondrial enzyme responsible for the metabolism of toxic aldehydes, including the removal of 4-hydroxynonenal (4-HNE). This aldehyde is generated by the lipidic peroxidation of the mitochondrial membrane and induces covalent modification of important biomolecules including proteins (Michaelis adducts). The results of adducts formation are protein inactivation and cellular dysfunction. We demonstrated recently that besides 4-HNE, malondialdehyde and acetaldehyde are involved in inflammatory nociception and that ALDH2 is a key enzyme for the pain control. In this talk, I will show you that using gain and loss of function strategies we propose the involvement of this mitochondrial enzyme on the development and progression of an experimental chronic pain models.
Ministrante: Profa. Dra. Vanessa Olzon Zambelli Visiting Researcher, Anesthesia Department, Stanford University (present); Principal Investigator, Laboratory of Pain and Signaling, Butantan Institute (2013-present); MBA in Health and Innovation Management (2017-2018); Postdoctoral Fellow, Dept. of Chemical & Systems Biology, Stanford University (2011-2012); PhD in Pharmacology, University of Sao Paulo, Brazil (2006-2011); Master in Pharmacology, University of Sao Paulo, Brazil (2006); Bachelor in Biomedical Sciences, State of Sao Paulo University, Brazil (2000-2003).